Biosynthesis of nonribosomal peptides

By Robert Finking, Mohamed A. Marahiel. 2003

794 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d6a0c841f5813df7cc12bbe6568a0a6aee6c996c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Ongena
2. J. Raaijmakers
3. Robert E. W. Hancock
4. I. de Bruijn
5. O. Nybroe
6. J. Loper
7. J. Bennett
8. H. Sahl

In Pharmacology

1. J. Raaijmakers
2. I. de Bruijn
3. O. Nybroe
4. M. Ongena
5. Robert E. W. Hancock
6. J. Loper
7. J. Bennett
8. N. Keller

Citations in the corpus

• Cyanobacterial peptides - nature's own combinatorial biosynthesis. (2006, background): “Non-ribosomal peptide synthetases -- a short introduction The non-ribosomal peptide biosynthetic system operates nucleic acid-free at the protein level (Finking & Marahiel, 2004; Sieber & Marahiel, 2005).”
• Fungal secondary metabolism — from biochemistry to genomics (2005, background): “Non-ribosomal peptides are derived from both PROTEINOGENIC AMINO ACIDS and non-proteinogenic amino acids by multidomain, multimodular enzymes named non-ribosomal peptide synthetase”
• Surfactin and Other Lipopeptides from Bacillus spp. (2011, background): “Since this discovery, many works were carried out to describe in detail the non-ribosomal peptide biosynthesis (Finking and Marahiel 2004).”
• Genomic analysis of antifungal metabolite production by Pseudomonas fluorescens Pf-5 (2007, background): “NRPSs are large, multifunctional enzymes that are organized into modules, each of which synthesizes the addition of an amino acid to a peptide, which is then transferred to downstream modules for the next step in the synthesis of an elongating peptide chain (Finking and Marahiel 2004).”
• Bacillus subtilis antibiotics: structures, syntheses and specific functions (2005, background): “The huge potential of NRPSs and PKSs in the generation of novel drugs has been excellently reviewed elsewhere (Sieber and Marahiel, 2003; Finking and Marahiel, 2004; Walsh, 2004).”
• Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics. (2010, background): “NRPSs possess a modular structure and each module is a building block for the stepwise incorporation of an amino acid in the LP peptide moiety (Finking & Marahiel, 2004; Fischbach & Walsh, 2006; Gross & Loper, 2009; Marahiel & Essen, 2009).”
• Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies (2006, background): “In addition to ribosomally synthesized antimicrobial peptides, microbes also produce peptide antibiotics of broad structural diversity using large multifunctional enzymes, the so-called nonribosomal-peptide synthetase”