Fungal secondary metabolism — from biochemistry to genomics

By N. Keller, G. Turner, J. Bennett. Nature Reviews Microbiology, 2005

1,644 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7cc9496750d82e5d839159e7489e63351b404ea6

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Citations in the corpus

Endophytic Fungi: Natural Products, Enzymes and Biotransformation Reactions (2009, background): “The products of these pathways include important therapeutic drugs such as antibiotics, immunosuppressants and antihyperlipidemics, as well as potent poisons, including aflatoxins and trichothecenes [194].”
Trichoderma reesei: A Fungal Enzyme Producer for Cellulosic Biofuels (2011, background): “In the case of secondary metabolite biosynthetic genes, clustering has been suggested to reflect their evolutionary history (Keller et al., 2005; Zhang et al., 2004).”
Extensive sampling of basidiomycete genomes demonstrates inadequacy of the white-rot/brown-rot paradigm for wood decay fungi (2014, background): “Secondary metabolites include polyketides, nonribosomal peptides, and terpenoids, among many other substances that are not considered to be critically involved in an organism’s growth, development, and reproduction, but that typically confer some advantage in the never-ending competition with other ”
The decomposition of ectomycorrhizal fungal necromass (2016, background): “Fungi produce a myriad of other secondary compounds that likely influence the decomposition of their tissues (Keller et al., 2005).”
Cochliobolus: an overview and current status of species (2011, background): “Novel metabolites and toxins produced by Cochliobolus species The fungal kingdom includes many species with unique and unusual biochemical pathways (Keller et al. 2005).”
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 (2007, background): “Secondary metabolism and safety Among the secondary metabolites produced by filamentous fungi, mycotoxins are most relevant from a safety point of vie”
Genomic Analysis of the Necrotrophic Fungal Pathogens Sclerotinia sclerotiorum and Botrytis cinerea (2011, methodology): “Generally in fungi, all genes from a SM cluster are involved in the same metabolic pathway and are co-regulated [111,113,114].”
Trichoderma Secondary Metabolites Active on Plants and FungalPathogens (2014, background): “In fungi, the production of SMs has been often correlated to specific stages of morphological differentiation, and associated to the phase of active growth [7] [8] [9].”
SMURF: genomic mapping of fungal secondary metabolite clusters (2010, neutral): “The HMMER program (http://hmmer.janelia.org) was used to search for conserved Pfam and TIGRFAM domains of backbone enzymes in the protein set of each sequenced species.”