Hyperactive Ras in developmental disorders and cancer

By Suzanne Schubbert, K. Shannon, G. Bollag. Nature Reviews. Cancer, 2007

1,002 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “Mutations of K-Ras occur frequently in many human cancers including those of the lung and colon [145].”
Molecular mechanisms of cancer development in obesity (2011, background): “Activation of these receptors results in the phosphorylation of the IRS proteins, which activate the oncogenic RAS–MAPK and PI3K–AKT pathway”
Senescence in tumours: evidence from mice and humans (2010, neutral): “Costello syndrome increases the susceptibility to papilloma, rhabdomyosarcoma and bladder carcinoma developmen”
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches (2012, background): “Constitutive MAPK and PI3K pathways activation is a frequent event in human cancer, as a result of molecular alterations in genes encoding key components of the pathways or upstream activation mediated by mutations or amplification of cellsurface receptors [1,2].”