Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial.

By C. Soares, O. Almeida, H. Joffe, L. Cohen. Archives of General Psychiatry, 2001

701 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d6398258b97e906f974af2e84d8f33c392c570a7

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In Genetics

1. C. N. Epperson
2. N. Sarvaiya
3. M. Altemus

Citations in the corpus

• Handbook of Clinical Sexuality for Mental Health Professionals (2004, background): “The risk of depression is increased two- to four-fold in the perimenopause versus among reproductive-age women([7]), and such depression may be responsive to treatment with transdermal estradiol([8]).”
• Hormones and menopausal status as predictors of depression in women in transition to menopause. (2004, neutral): “Premenopausal 34 (10) 41 (13) 29 (10) 28 (9) 39 (13) 33 (11) Early transition 0 7 (2) 1 ( 1) 6 (2) 7 (2) 14 (4) Late transition 0 1 ( 1) 0 0 1 ( 1) 0 Postmenopausal 0 0 0 0 0 1 ( 1) Total 34 (10) 49 (15) 30 (10) 34 (11) 47 (16) 48 (15)”
• Sex differences in anxiety and depression clinical perspectives (2014, background): “In addition, two randomized clinical trials (Schmidt et al., 2000; Soares et al., 2001) indicate that typical hormone therapy doses of estradiol (50 or 100 lg/d) are significantly more effective than placebo in treating major depression with perimenopause onset, a finding that is lacking for major…”
• Neuroendocrine pharmacology of stress. (2003, background): “, 2002), is a promising treatment of depression (Dayas et al., 2000; Fink et al., 1996; Gregoire et al., 1996; Soares et al., 2001).”
• The stress system in the human brain in depression and neurodegeneration. (2005, background): “Women with both of these estrogen and, hence, CRH withdrawal states, do show mood improvements with estrogen therapy (Soares et al., 2001).”
• Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods (2015, background): “…system for some of the potential antidepressant benefits estrogen use in HRT may have for women during specific windows of time: Some studies suggest that estrogen might be useful to target perimenopausal (Schmidt et al., 2000; Soares et al., 2001), but not postmenopausal (Morrison et al., 2004).”
• Associations of hormones and menopausal status with depressed mood in women with no history of depression. (2006, neutral): “Married or living with partner 74 (64) 71 (66) .76 Other 42 ( 36 ) 37 (34)”