Hormones and menopausal status as predictors of depression in women in transition to menopause.

By E. Freeman, M. Sammel, Li Liu, C. Gracia, D. Nelson, Lori Hollander. Archives of General Psychiatry, 2004

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Major depression after breast cancer: a review of epidemiology and treatment. (2008, background): “Decline in estrogen, not the level of estrogen, remains a leading hypothesis regarding the high rate of reproductive endocrine-associated affective symptoms and depressive disorders seen in periods of acute estrogen decline [165–168].”
Associations of hormones and menopausal status with depressed mood in women with no history of depression. (2006, methodology): “These results add support to the findings of Schmidt et al,(12) who reported a similar frequency of new onset of majororminordepression in themenopausal transition(21% vs 26% in the present study in which the women were followedup3years longer) and to thegrowingepidemiologic evidence that depressive”
Handbook of Clinical Sexuality for Mental Health Professionals (2004, background): “The risk of depression is increased two- to four-fold in the perimenopause versus among reproductive-age women([7]), and such depression may be responsive to treatment with transdermal estradiol([8]).”