Signaling in Adult Neurogenesis

By Yangling Mu, Star W. Lee, Fred H. Gage. 2010

532 citations recorded by the source corpus.

Neural stem cells (NSCs) in the adult brain continuously supply new neurons to the hippocampal dentate gyrus (DG) and the olfactory bulb (OB). Recent studies indicate that the progression from neural precursor cells (NPCs) to mature neurons is tightly controlled by coordinate cell-intrinsic programs and external signals within the neurogenic niche. In this review, we summarize both classes of regulatory factors involved in distinct stages of adult neurogenesis, including proliferation and lineage differentiation of NSCs, migration of neuroblasts and integration of newborn neurons. A full understanding of the wide variety of signaling pathways will ultimately provide precise targets for therapeutic applications.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Many molecular players and signaling pathways have been identified, including niche factors/receptors, cytoplasmic factors, transcriptional factors, and epigenetic regulators (reviewed by Ma et al., 2010; Mu et al., 2010; Ninkovic and Gö tz, 2007; Sun et al., 2011).”
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Furthermore, each of these processes is subject to regulation by numerous intrinsic and extrinsic factor”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “Generally, adult neurogenesis proceeds through four developmental stages (Christie and Cameron, 2006; Lie et al., 2004; Ming and Song, 2005; Zhao et al., 2008; Suh et al., 2009): (1) proliferation of neural stem/progenitor cells (NSCs), (2) neuronal fate determination of NSCs, (3) maturation and mig”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Among neighboring cells, several lines of evidence indicate endothelial cells as exerting a pivotal role (38, 222).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, background): “Although neural stem cells (NSCs) that show neurogenic potential in vitro can be isolated from various adult brain regions, only the SVZ and the DG produce substantial numbers of new neurons throughout life (4).”
Epigenetic choreographers of neurogenesis in the adult mammalian brain (2010, background): “Niche signaling molecules have been shown to regulate various process in adult neurogenesi”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “Several signaling molecules, such as Wnt, Notch, Shh and BMP, as well as growth and neurotrophic factors and neurotransmitters, were found to regulate hippocampal neurogenesis [206–210].”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Serotonergic neurons originating from the dorsal raphe nuclei (DGN) send projections to the dentate gyrus and serotonergic signaling has been implicated in mood regulation (Jacobs et al., 2000; Suh et al., 2009).”
Adult hippocampal neurogenesis and its role in Alzheimer's disease (2011, background): “Two types of NSCs have been identified based on their specific morphologies, proliferative behaviors and expression of unique sets of molecular markers (reviewed in [16]).”
Neurodegenerative disease and adult neurogenesis (2011, background): “The hippocampus- or OB-dependent functions in the formation of new memories, acquisition of new skills and olfactory learning may in part be attributable to adult neurogenesis at different stages (reviewed in Mu et al., 2010; Aimone et al., 2010; Ma et al., 2010).”