Necroptosis as an alternative form of programmed cell death

By Dana E Christofferson, Junying Yuan. Current Opinion in Cell Biology, 2010

770 citations recorded by the source corpus.

Summary The family of death receptors plays a critical role in regulating cell number and eliminating harmful or virally infected cells. Agonistic stimulation of death receptors is known to lead two alternative cell fates by either activating NF-κB to promote cell survival or inducing apoptosis to lead to cell death; and now a third pathway, termed necroptosis or programmed necrosis has been identified. Interestingly, a death-domain containing kinase, RIP1, is involved in mediating all 3 pathways, with its kinase activity specifically involved in regulating necroptosis. The availability of necrostatin-1, a specific inhibitor of RIP1 kinase, made it possible to dissect the distinct functional domains of RIP1. Recent genome-wide siRNA screens have identified multiple players of necroptosis that may interact with and/or regulate RIP1 kinase and mediate the signaling pathway and execution of necroptosis. Necroptosis and necrostatins provide an exciting new opportunity for developing new treatments for multiple human diseases involving necrosis and inflammation.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/d5eec09a9bb52b3ebe6478ac9a9b329126a0c002

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Citations in the corpus

Ferroptosis: an iron-dependent form of nonapoptotic cell death. (2012, background): “…apoptosis-inducing factor 1 (AIF1)dependent parthanatos, caspase-1-dependent pyroptosis, and receptor-interacting protein kinase 1 (RIPK1)-dependent nec- 1060 Cell 149, 1060–1072, May 25, 2012 ª2012 Elsevier Inc. roptosis (Bergsbaken et al., 2009; Christofferson and Yuan, 2010; Wang et al., 2009).”
Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “Binding of TNF α to TNFR1 leads to its internalization and the formation of a cytosolic death-inducingsignalingcomplex(DISC), alsoknown as complex II [24,31].”
Anti-apoptosis and cell survival: a review. (2011, background): “For example, in addition to activating apoptosis, stimulation of TNF-α receptors can also lead to the induction of a programmed from of necrosis called necroptosis [28].”
Cell Death Signaling. (2015, neutral): “4C, left panel) (Christofferson and Yuan 2010; Declercq et al. 2009).”
The Development of the Concept of Ferroptosis (2018, neutral): “two decades until it was widely accepted that ‘necroptosis’ should be classified as a form of regulated cell death [15,16].”