Ferroptosis: an iron-dependent form of nonapoptotic cell death.

By Scott J. Dixon, K. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, Caroline E. Gleason, Darpan N. Patel, Andras J. Bauer, Alexandra M. Cantley, W. Yang and 2 more. Cell, 2012

15,723 citations recorded by the source corpus.

Subfields: Epidemiology, Nutrition and Dietetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/85891b334a1332619046d880c56b2ad9cccf029a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. N. Mizushima
4. L. Galluzzi
5. D. Klionsky
6. Douglas R. Green
7. I. Slaninová
8. Brent R. Stockwell

In Nutrition and Dietetics

1. D. Tang
2. Brent R. Stockwell
3. R. Kang
4. Scott J. Dixon
5. M. Conrad
6. W. Yang
7. J. Cao
8. Guido Kroemer

In Pulmonary and Respiratory Medicine

1. Brent R. Stockwell
2. D. Tang
3. R. Kang
4. Guido Kroemer
5. M. Conrad
6. Scott J. Dixon
7. Tal Hirschhorn
8. Xin Chen

Citations in the corpus

• Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model (2019, background): “, 2017); inhibition of system xc – can induce ferroptosis through cysteine deprivation (Dixon et al., 2012), subsequent glutathione (GSH) depletion, and ultimately inactivation of GSH peroxidase 4 (GPX4) (Yang et al.”
• Ferroptosis, necroptosis, and pyroptosis in anticancer immunity (2020, background): “Glutamate Nutrient System Xc- Ferroptosis induction [59] Increased immune suppression [122]”
• Autophagy promotes ferroptosis by degradation of ferritin (2016, background): “, HT-1080 and BJeLR).(5) However, whether genetic inhibition of the autophagic pathway regulates the process and function of ferroptosis is unclear.”
• Cell Death Signaling. (2015, background): “2004), ferroptosis (Dixon et al. 2012), and others.”
• Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options (2022, background): “Ferroptosis, a reactive oxygen species-α-dependent form of cell death defined by iron-dependent accumulation and lipid peroxides that differs from other types of cell death in biochemistry, morphology, and primary regulatory mechanisms [60], plays a role in the onset and progression of sepsis [61, 6”
• RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer (2018, background): “This process is characterized by suppression of the phospholipid glutathione peroxidase 4 (GPX4) and subsequent intracellular accumulation of lipid reactive oxygen species (ROS) in an irondependent manner (Dixon et al., 2012; Yang et al., 2014).”