Diversity and clonal selection in the human T-cell repertoire
By Q. Qi, Yi Liu, Yong Cheng, J. Glanville, David W. Zhang, Ji-Yeun Lee, Richard A. Olshen, C. Weyand, S. Boyd, J. Goronzy. Proceedings of the National Academy of Sciences of the United States of America, 2014
723 citations recorded by the source corpus.
Subfields: Endocrinology, Immunology
View Paper: https://www.semanticscholar.org/paper/d5ed50676811c3837a90c7e6562ab64d34fc011c
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In Immunology
Citations in the corpus
- Quantifying lymphocyte receptor diversity (2016, positive): “Dividing the dataset into 5 subsamples as in [28], and calculating Chao2 yields a similar estimate, 3.”
- Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity (2020, neutral): “A repertoire of fewer naive T cells in older individuals (Briceño et al., 2016; Qi et al., 2014) may be exacerbated as a risk factor specifically for severe COVID19, because early innate immune evasion by SARS-CoV-2 may limit T cell priming (Blanco-Melo et al.”
- VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires (2015, background): “Notably, lower bound estimates of total repertoire diversity that are especially affected by sampling bias were applied in some recent studies for the comparison of TCR repertoire diversity under uneven sample sizes [9,52].”
- Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, neutral): “Notably, it is well characterized that the abundance of naive T cells declines substantially with age (Briceño et al., 2016; Qi et al., 2014; Wertheimer et al., 2014).”
- VDJdb: a curated database of T-cell receptor sequences with known antigen specificity (2017, methodology): “…the utility of VDJdb as a tool for the annotation of large-scale RepSeq data, we selected two recently published datasets: (i) TCR sequences from CD4 and CD8 T-cell subsets isolated from donors stratified for age and CMV status (15); and (ii) pooled TCR sequences from an aging study (16).”
- Human T cell development, localization, and function throughout life (2018, background): “…cells in the blood of elderly individuals (70–85 years old) still maintain a diverse repertoire of unique TCRβ amino acid sequences that while reduced compared to that of young adults (Qi et al., 2014), suggests that humans are capable of responding to novel antigens even at advanced ages.”