Adaptive immunity to SARS-CoV-2 and COVID-19
By Alessandro Sette, Shane Crotty. Cell, 2021
1,701 citations recorded by the source corpus.
The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infections and in vaccines, and thus it is critical to directly study adaptive immunity to SARS-CoV-2 to understand COVID-19. Knowledge is now available on relationships between antigen-specific immune responses and SARS-CoV-2 infection. Although more studies are needed, a picture has begun to emerge that reveals that CD4+ T cells, CD8+ T cells, and neutralizing antibodies all contribute to control of SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19. The specific functions and kinetics of these adaptive immune responses are discussed, as well as their interplay with innate immunity and implications for COVID-19 vaccines and immune memory against re-infection.
Subfields: Infectious Diseases, Neurology
View Paper: https://www.semanticscholar.org/paper/f5f4376f34df880d816b4c86b24b48f455dc80a2
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Citations in the corpus
- COVID-19 and the human innate immune system (2021, background): “discussed in greater detail elsewhere (Sette and Crotty, 2021), NK cells are affected as well (Giamarellos-Bourboulis et al., 2020a; Hadjadj et al., 2020; Kuri-Cervantes et al., 2020; Zheng et al., 2020a).”
- SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron (2022, neutral): “Adaptive immunity against SARS-CoV-2 consists of multiple branches (Sette and Crotty, 2021).”