Proteostasis and aging

By Susmita Kaushik, A. Cuervo. Nature Medicine, 2015

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How researchers see this paper

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Cellular Senescence: Defining a Path Forward. (2019, positive): “Proteotoxicity is a hallmark of aging and cellular senescence (Kaushik and Cuervo, 2015).”
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets (2023, background): “Protein quality control systems are responsible for maintaining proteostasis, including chaperones, ATPases, glucose-regulated protein 94 (Grp94), BiP (an Hsp70 family member), and two proteolytic systems: the ubiquitin–proteasome and the lysosome–autophagy systems.(3) Misfolded proteins produced un”
Benefits of Metformin in Attenuating the Hallmarks of Aging (2020, background): “Aging, age-associated pathologies and neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases, exhibit an impaired network of coordinated proteostasis, with the accumulation of intracellular damage (Kaushik and Cuervo 2015).”
Mechanisms of Vascular Aging (2018, background): “Aging impacts multiple components of the proteostasis systems in heart and the vasculature, including chaperones,(102) the ubiquitin-proteasome, and the lysosome-autophagy system.(98)”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “They have now been shown to play a crucial role in intercellular communication through the intercellular transfer of nucleic acids and specific repertoires of proteins and lipids, which is important for protein and lipid homeostasis [2].”