Benefits of Metformin in Attenuating the Hallmarks of Aging

By Ameya Sadguru Kulkarni, Sriram Gubbi, Nir Barzilai. Cell Metabolism, 2020

641 citations recorded by the source corpus.

SUMMARY Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin- a biguanide that combats age-related disorders and improves healthspan, is the first drug to be tested for its age-targeting effects in the large clinical trial- TAME (Targeting Aging by MEtformin). This review focuses on metformin’s mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient-sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem-cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/8e49e4db85b0f5e33017ab171114e9fa35d5eb96

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Citations in the corpus

• Senescence and the SASP: many therapeutic avenues (2020, background): “Glucocorticoid treatment decreases the production of selected components of the SASP, namely, proinflammatory cytokines like IL-6, across different inducers of senescence by inhibiting NF-κB (Laberge et al. 2012).”
• Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “In addition to promoting senolysis, the senomorphic drugs resveratrol and metformin can ameliorate β-cell senescence and improve metabolic balance in animal models.(574,575) In diabetic individuals, metformin is suggested to improve glucose tolerance and insulin sensitivity by reducing telomere shor”