Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1

By K. Ohashi, V. Burkart, S. Flohé, H. Kolb. Journal of Immunology, 2000

1,779 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d5800415be19fb8e5094356e83e1276bf8b804ae

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In Immunology

1. Shizuo Akira
2. K. Takeda
3. T. Mogensen
4. S. Ghosh
5. O. Takeuchi
6. R. Medzhitov
7. T. Kaisho
8. Taro Kawai

In Molecular Biology

1. Shizuo Akira
2. O. Takeuchi
3. K. Takeda
4. T. Mogensen
5. S. Ghosh
6. H. Kono
7. K. Rock
8. T. Wyss‐Coray

Citations in the corpus

• Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease (2000, background): “Moreover, TLR4 upregulation could also result from the effects of ligands other than LPS (20, 29).”
• Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “…by CNS trauma or disease (e.g., heat-shock proteins [HSPs], highmobility-group box protein 1 [HMGB1], fibrinogen, hypomethylated mammalian DNA, and RNA released from necrotic cells) (Kariko et al., 2004; Leadbetter et al., 2002; Ohashi et al., 2000; Smiley et al., 2001; Viglianti et al., 2003).”
• Macrophage activation by endogenous danger signals (2008, background): “In macrophages, HSP60 induces the production of NO and TNFα via TLR4 [53].”
• Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation (2010, background): “In addition to TLRs, an abundance of TLR ligands, both bacterial [45] and endogenous [46–49], has been demonstrated in atherosclerotic lesions.”
• Pattern recognition receptors and inflammation. (2010, background): “Furthermore, heat shock proteins (HSPs) such as HSP60, HSP70, gp96, and HSP22 are also reported to be recognized by TLR2 and TLR4 (Asea et al., 2002; Ohashi et al., 2000; Roelofs et al., 2006; Warger et al., 2006).”
• Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide (2003, background): “Thus, this is the case for HSP, HSP-60 (10), HSP70 (12), and GP96 (11), heparan sulfate (33), surfactant protein A (34), and the product of degradation of the extracellular matrix hyaluronic acid (14).”