ReviewThe Hippocampal-VTA Loop : Controlling the Entry of Information into Long-Term Memory

By John E. Lisman, Anthony A. Grace. 2005

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neuroscience

Citations in the corpus

Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis (2006, background): “…to the dopamine hypothesis because results thus far point to important interactions between dopamine receptors and NMDAR in critical brain regions such as the hippocampus (Lisman and Otmakhova, 2001) and between glutamatergic afferents and subcortical dopaminergic nuclei (Lisman and Grace, 2005).”
Synaptic Consolidation: From Synapses to Behavioral Modeling (2015, background): “Experimental work (Frey et al., 1990; Sajikumar and Frey, 2004b; Lisman and Grace, 2005) has linked the production of PRP and the maintenance of memory to the presence of neuromodulators such as dopamine.”
Control of mental activities by internal models in the cerebellum (2008, background): “The novelty system has been suggested to consist of the hippocampal CA1 area and dopaminergic neurons in the ventral tegmental area (VTA”
The restless engram: consolidations never end. (2012, background): “Since, in real life, the subject is not naive to at least part of the information presented (see above), a tension is expected between episodic encoding and retrieval in the learning situation, with the two modes temporally segregated and interchanging within fractions of a second to seconds (Hassel”
Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “Glucocorticoids modulate firing of DA neurons (Piazza et al., 1996a; Piazza et al., 1996b), and regions that suffer glucocorticoid-mediated atrophy are key regulators of mesolimbic and mesocortical DA projection pathways (Arnsten, 2009; Lisman and Grace, 2005).”
States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit (2014, background): “This account is admittedly speculative, but it aligns with models (Goto and Grace, 2008; Lisman and Grace, 2005; Scimeca and Badre, 2012) proposing that the VTA signals salience, whereas the nucleus accumbens integrates information about salience from the VTA with information about goal-relevance…”
The Hierarchical Organisation of Cortical and Basal-Ganglia Systems: A Computationally-Informed Review and Integrated Hypothesis (2013, unknown): “…level, the hierarchy also involves the amygdala complex (Mirolli et al., 2010; Pitkänen et al., 1997) and the hippocampal system (Bast, 2007; Lisman and Grace, 2005; Voorn et al., 2004) as generators of motivations and as loci of associations between objects/experiences and their…”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “It has been hypothesized that an indirect excitatory projection from hippocampus to VTA is critical for coordinating the firing of VTA cells in response to novelty (Lisman and Grace, 2005); impairment of this hippocampal function could thus lead to reduced dopaminergic tone and contribute to anhedon”
Novelty or Surprise? (2013, background): “In fact, not surprisingly in human experiments with novel images, it is the hippocampus that seems to be involved (e.g., Lisman and Grace, 2005), whereas light ﬂashes trigger dopamine activity via the superior colliculus, which directly projects to the dopaminergic neurons (Dommett et al., 2005).”
Intrinsic motivations and open-ended development in animals, humans, and robots: an overview (2014, background): “The computational work of Lonini et al. (2013) builds on a previous binocular system in which an IM learning signal is generated on the basis of the capacity of the system to reconstruct images encoded with sparse-coding features.”
Integrating Memories in the Human Brain: Hippocampal–Midbrain Encoding of Overlapping Events (2008, background): “…(i.e., F 1 versus F 2 ) may trigger a mismatch signal within the hippocampus that upregulates midbrain dopaminergic feedback onto the hippocampus (Lisman and Grace, 2005), the consequence of which is to increase the probability of encoding the present and prior event features into an integrated…”
What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated. (2016, unknown): “A wide range of factors may affect the signi ﬁ cance of individual experiences [82,83]: for example, they may be surprising or novel; high in reward value (either positive or negative) or in their informational content (e.g., in reducing uncertainty about the best action to take in a given state).”