Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features.

By Greg J. Siegle, Wesley K. Thompson, Cameron S. Carter, S. Steinhauer, M. Thase. Biological Psychiatry, 2007

885 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d53a3d06cd18548f4ce555a2ab4815cfd3cde6e0

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Citations in the corpus

Frontocingulate Dysfunction in Depression: Towards Biomarkers of Treatment Response (2010, background): “…by reduced ability to recruit the DLPFC (Fales et al, 2008; Holmes and Pizzagalli, 2008b; Mitterschiffthaler et al, 2008; Wang et al, 2008a, 2008b; Siegle et al, 2007) and dACC (Fales et al, 2008; Wang et al, 2008a, 2008b) when required to ignore task-irrelevant negative cues or adjust behavior…”
Default Mode Network Mechanisms of Transcranial Magnetic Stimulation in Depression (2014, result): “In addition to these DMN findings, we also observed a pattern of widespread hypoconnectivity within the central executive network that has not, to our knowledge, been reported in prior rs-fMRI studies, but is consistent with previous findings of decreased activity during various cognitive tasks (53,”
The Role of Sleep in Emotional Brain Function (2014, background): “…reported in several affective psychopathologies, including major depression, bipolar disorder, generalized anxiety disorder and PTSD (Davidson 2002, Drevets et al 2008, Etkin 2010, Etkin & Wager 2007, Nitschke et al 2009, Paulus & Stein 2006, Rauch et al 2000, Shin et al 2006, Siegle et al 2007).”
Cognitive therapy vs. medications for depression: Treatment outcomes and neural mechanisms (2008, background): “, with the most-consistent evidence suggesting increased and relatively unmodulated amygdala activit”
Emotion Regulation in Depression: Relation to Cognitive Inhibition (2010, background): “For example, Siegle, Thompson, Thase, Steinhauer, and Carter ( 2007 )) presented preliminary data demonstrating that a brief intervention targeted at increasing cognitive control in severely depressed out-patients led to significant decreases in both depressive symptoms and rumination.”
Emotion regulation in depression: Examining the role of cognitive processes (2010, result): “In support of these theories, research has found that people exposed to the same event display a wide variety of emotional responses depending on their appraisals of the event (eg, Siemer et al, 2007 ).”