The plasminogen activation system in tumor growth, invasion, and metastasis

By P. Andreasen, R. Egelund, H. H. Petersen. Cellular and Molecular Life Sciences (CMLS), 2000

973 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/d5266ce04a94ee57a3282ecdaca1bec83e09c77f

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Citations in the corpus

The pharmacological landscape and therapeutic potential of serine hydrolases (2012, background): “, urokinase-type plasminogen activator and tissue-type plasminogen activato”
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. (2002, neutral): “They serve to focus the enzymatic activity on a cell surface or at a cell-extracellular matrix interface, as for urokinase and plasminogen/plasmin (23).”
Tumor-stroma interactions in pancreatic ductal adenocarcinoma (2007, background): “has other roles in cancer progression that as a mere matrix protease inhibitor (28).”
Mathematical modelling of cancer cell invasion of tissue (2005, background): “Plasmin: In examining the conservation of mass regarding plasmin concentration, we assume that binding of uPA/uPAR provides the cell surface with a potential proteolytic activity via activation and cell-surface co-localization of plasminogen and thus enhances rates of plasmin formation,(10,33,11) wh”
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence (2006, neutral): “As inhibition of PAI-1 expression leads to activation of uP”
Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis (2001, background): “The phase of activation encompasses (1) increased vascular permeability and extravascular fibrin deposition; (2) vessel wall disassembly; (3) basement membrane degradation; (4) cell migration and ECM invasion; (5) endothelial cell proliferation; and (6) capillary lumen formation.”
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “Paradoxically, PAI-1 is involved in tumor growth, invasion, metastasis, and angiogenesis by interacting with vitronectin, integrins, and other components of the uPA system and by affecting the extracellular matrix (94-96).”