Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis

By M. Pepper. Arteriosclerosis, Thrombosis and Vascular Biology, 2001

787 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/1cd39f5963a39890224a20b1692b5450fc5de7bd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Khalil
2. Xi Wang
3. James P. Quigley
4. Jian Wang
5. R. Roskoski
6. A. Newby
7. E. Deryugina
8. S. Doré

In Hematology

1. James P. Quigley
2. Xi Wang
3. R. Khalil
4. Jian Wang
5. R. Roskoski
6. A. Newby
7. E. Deryugina
8. S. Doré

In Oncology

1. R. Khalil
2. Xi Wang
3. D. Bar-Sagi
4. Y. Pylayeva-Gupta
5. James P. Quigley
6. Jian Wang
7. R. Roskoski
8. A. Newby

Citations in the corpus

• Inflammation after Intracerebral Hemorrhage (2007, background): “…and Mun-Bryce, 2004; Wang and Lo, 2003), but because MMPs are essential for neurogenesis, myelin formation, and axonal growth (Cunningham et al, 2005; Kaczmarek et al, 2002; Pepper, 2001; Yong, 2005), there are concerns that inhibiting MMPs during recovery from ICH could do more harm than good.”
• Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. (2005, background): “Indeed, MMPs have an established role in angiogenesis (212), which appears to contribute to plaque growth (193) as well as being a histological feature associated with unstable plaques (127, 185).”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “The pregnancy-associated increases in vascular MMPs could play a role in vascular remodeling, angiogenesis, and the systemic changes in blood vessels (Pepper, 2001a).”
• RAS oncogenes: weaving a tumorigenic web (2011, background): “Oncogenic HRAS G12V -mediated upregulation of matrix metalloproteinase 2 (MMP2), MMP9 and urokinase-type plasminogen activator (uPA) has been shown to be instrumental in removing the physical confines of the basement membrane, with upregulation of uPA especially important in potentiating endothelial”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Extracellular matrix (ECM) remodeling, including the degradation of the connective tissue and basement membrane proteins, is necessary during the early stage of angiogenesis (179, 180).”
• Matrix metalloproteinases and tumor metastasis (2006, background): “The role of lymphatic vasculature as a route for tumor cell dissemination has been established [151, 152], however it is not definitively confirmed how this route is related to the formation of metastases in secondary sites [2, 3].”
• Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “The matrix metalloproteases have the potential to nhance angiogenesis by liberating non-diffusible VEGF rom the extracellular matrix [198], and they also mediate xtracellular matrix breakdown that promotes angiogeneis and metastasis [200,201].”
• Matrix metalloproteinase-9: Many shades of function in cardiovascular disease. (2013, background): “Proteolytic enzymes, such as plasmin, urokinasetype plasminogen activator, and tissue-type plasminogen activator, are capable of cleaving the pro-domain to activate MMP-9 (92).”