Tumor-stroma interactions in pancreatic ductal adenocarcinoma

By D. Mahadevan, D. V. Von Hoff. Molecular Cancer Therapeutics, 2007

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Advanced pancreatic carcinoma: current treatment and future challenges (2010, background): “There is a complex interplay between tumor and stromal cells, which leads to the activation of signaling pathways (such as TGF-b/SMAD, HGF/Met, matrix metalloproteinases, Hedgehog, Wnt) through autocrine and paracrine mechanisms and the establishment of a dynamic microenvironment that promotes tumor”
Stromal biology and therapy in pancreatic cancer (2010, background): “The stromal microenvironment is a complex structure composed of an extracellular matrix (ECM), activated fibroblasts and myofibroblasts, inflammatory cells and blood and lymphatic vessels that distort the normal architecture of pancreatic tissue. Interactions between the neoplastic and non-neoplasti”
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes (2018, background): “that is a hallmark of the PDAC microenvironment.(33) The microenvironment of PDAC was more heavily 297 infiltrated with CD45 immune cells than the normal pancreas, and the intestinal mucosa of the small intestine 298 was also replete with immune cells, consistent with the known architecture and orga”