Nanomechanical analysis of cells from cancer patients.

By S. Cross, Yu Jin, J. Rao, J. Gimzewski. Nature Nanotechnology, 2007

1,875 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Physical and Theoretical Chemistry

View Paper: https://www.semanticscholar.org/paper/d491204fad475a666f3bb1fe902c76c57a202a50

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In Atomic and Molecular Physics, and Optics

In Cell Biology

In Physical and Theoretical Chemistry

Denis Wirtz

Citations in the corpus

Hydrodynamic stretching of single cells for large population mechanical phenotyping (2012, background): “Further, the ability to measure whole-cell deformation of spherical cells in suspension limits variability due to the contact point of AFM tips or micropipettes on mechanically heterogeneous attached cells (e.g., significant differences in stiffness in the vicinity or far from actin stress fibers) (”
Nanotechnology for Early Cancer Detection (2010, background): “Histograms of the measured elasticity showed significant difference between cancer cells and normal cells, with cancer cells having a stiffer elasticity and a narrower distribution [130].”
A tense situation: forcing tumour progression (2009, background): “1 ) and that each cellular component within a tissue has a unique rheology and a stiffness optimum that can change over the course of development (as in lung branching morphogenesis), in response to function (as during mammary gland lactation) or in pathological situations (as in atherosclerotic p”
Mechanical properties of biological specimens explored by atomic force microscopy (2013, background): “Cross et al [82, 83] reported that metastatic cancer cells are 70% softer than normal cells.”
PhD thesis (2020, background): “The difference in mechanical properties of normal and cancer cells is based on the difference in F-actin structures at the apical surface of these cell types (Cross et al., 2007; Haghparast et al., 2013; Lekka et al., 2012).”
Comparative advantages of mechanical biosensors (2011, background): “Measurement of the elastic properties of live cells has also been demonstrate”
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, neutral): “For instance, nuclear softening, which can occur in cancer cells (Cross et al., 2007; Guck et al., 2005), would promote nuclear flattening in response to force and subsequent YAP nuclear import.”
A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects (2014, background): “5 kPa, some four times lower than that of healthy cells [74].”
Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines (2011, background): “While cancer tissue has been found to be generally stiffer than normal tissue, recent studies have shown that cancer cells themselves are more compliant than normal cells (8).”