Comparative advantages of mechanical biosensors
By J. Arlett, E. Myers, Michael L. Roukes. Nature Nanotechnology, 2011
936 citations recorded by the source corpus.
Mechanical interactions are fundamental to biology. Mechanical forces of chemical origin determine motility and adhesion on the cellular scale, and govern transport and affinity on the molecular scale. Biological sensing in the mechanical domain provides unique opportunities to measure forces, displacements and mass changes from cellular and subcellular processes. Nanomechanical systems are particularly well matched in size with molecular interactions, and provide a basis for biological probes with single-molecule sensitivity. Here we review micro- and nanoscale biosensors, with a particular focus on fast mechanical biosensing in fluid by mass- and force-based methods, and the challenges presented by non-specific interactions. We explain the general issues that will be critical to the success of any type of next-generation mechanical biosensor, such as the need to improve intrinsic device performance, fabrication reproducibility and system integration. We also discuss the need for a greater understanding of analyte–sensor interactions on the nanoscale and of stochastic processes in the sensing environment.
Subfields: Atomic and Molecular Physics, and Optics, Electrical and Electronic Engineering
View Paper: https://www.semanticscholar.org/paper/28c692b76daa93de57c966eaad7bce17e8f1e53e
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In Atomic and Molecular Physics, and Optics
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Citations in the corpus
- Recent Advances in Biosensor Technology for Potential Applications – An Overview (2016, background): “The ability to fabricate such structures using semiconductor processing procedures bridged biophysics and bioengineering principles toward the progress of practical micro- and nano-electromechanical biosensors that can be produced in large quantities (Arlett et al., 2011).”
- Silicon Photonic Biosensors Using Label-Free Detection (2018, methodology): “For instance, the enzyme-linked immunosorbent assay 20 (ELISA), which has been the gold-standard method in biomarker detection and validated for more than 40 21 years, can obtain an ultra-low detection limit (∼ 1 pM) [6].”