Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

By X. Chen, Y. Ba, Lijia Ma, Xing Cai, Yuan Yin, Kehui Wang, Jigang Guo, Yujing Zhang, Jiangning Chen, Xing Guo and 19 more. Cell Research, 2008

4,599 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d46fcc89adce91f1324fbb08a788268548e9cc7d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Yongqian Shu
2. Ke Zen
3. P. Murphy
4. X. Chen
5. Leigh-Ann MacFarlane
6. E. J. Lee
7. Thomas D. Schmittgen
8. M. Jansson

In Molecular Biology

1. Jacob A O'Brien
2. Yongqian Shu
3. Leroy Hood
4. C. Peng
5. P. Murphy
6. X. Chen
7. Leigh-Ann MacFarlane
8. E. J. Lee

Citations in the corpus

• Exosomes Derived from Mesenchymal Stem Cells (2014, background): “Specific expression patterns of serum miRNAs have been identified in lung cancer, colorectal cancer, and diabetes, providing evidence that serum miRNAs can serve as potential biomarkers for detection of various cancers and other diseases [42].”
• Characterization of human plasma-derived exosomal RNAs by deep sequencing (2013, background): “This stability makes reproducible and consistent evaluation of blood-based non-coding RNA possible [51].”
• Circulating microRNAs in plasma of patients with gastric cancers (2010, background): “Recently, several studies have shown that microRNAs (miRNAs), which are involved in tumourigenesis and the development of various cancers, are stably detectable in plasma/ serum (Calin and Croce, 2006; Chen et al, 2008; Filipowicz et al, 2008).”
• Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. (2010, background): “These results were consistent with previously reported miRNA profiling results by Solexa deep sequencing.(14) We noticed that only miR-133a had a low level presence in the plasma; miR-1, miR-499 and miR-208a were undetectable.”
• Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer (2010, background): “also demonstrated that specific serum miRNA profiles can be identified in serum from patients with lung cancer, CRC, and diabetes patients.(12) Although the clinical significance of these findings has not been elucidated in detail, those findings demonstrated that circulating miRNAs could be noninva”
• MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “However, a combination of other theories collectively suggest it is possible that the circulating miRNAs are from lysed cells and their stability is due to binding of DNA, proteins and or lipids that protect them from degradation [355, 357, 358].”
• Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. (2012, background): “[59] identified specific expression patterns of serum miRNAs for lung cancer, colorectal cancer, and diabetes, providing evidence that serummiRNAs contain fingerprints for various diseases.”
• Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. (2010, methodology): “RNA isolation, Solexa sequencing, and qRT-PCR assay were described previously.(12) In each step from serum purification to qRT-PCR, an equal volume of serum was processed.”