Identification of Novel Genes Coding for Small Expressed RNAs

By M. Lagos‐Quintana, R. Rauhut, Winfried Lendeckel, Thomas Tuschl. Science, 2001

5,148 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d46c27dff0650201f57e7381cec549736377489f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. David P. Bartel
2. Carlo Maria Croce
3. Phillip D. Zamore
4. V. Narry Kim
5. Scott M. Hammond
6. Nikolaus Rajewsky
7. George A. Calin
8. Thomas Tuschl

In Molecular Biology

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Carlo Maria Croce
5. Scott M. Hammond
6. Thomas Tuschl
7. Nikolaus Rajewsky
8. Gregory J. Hannon

Citations in the corpus

• The microRNAs of Caenorhabditis elegans. (2003, background): “The lin-4 and let-7 stRNAs are now recognized as the founding members of a large class of ∼22-nt ncRNAs termed microRNAs (miRNAs), which resemble stRNAs but do not necessarily control developmental timing (Lagos-Quintana et al. 2001; Lau et al. 2001; Lee and Ambros 2001).”
• Inferring Noncoding RNA Families and Classes by Means of Genome-Scale Structure-Based Clustering (2007, background): “Starting with the discovery of microRNAs [1, 2, 3] and the advent of genome-wide transcriptomics [4,”
• Plant microRNA: a small regulatory molecule with big impact. (2006, background): “, 1993), they were not recognized until 2001 (Lee and Ambros, 2001; Lau et al., 2001; Lagos-Quintana et al., 2001).”
• The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. (2002, result): “This notion is supported by the finding that miRNAs represent a potentially large class of small RNAs, virtually all of which have unknown functions (Lagos-Quintana et al. 2001; Lau et al. 2001; Lee and Ambros 2001; Mourelatos et al. 2002).”
• Computational identification of plant microRNAs and their targets, including a stress-induced miRNA. (2004, methodology): “The primary method of identifying miRNA genes has been to isolate, reverse transcribe, clone, and sequence small cellular RNAs (Lagos-Quintana et al., 2001; Lau et”
• MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. (2008, methodology): “Subsequently, another method reported that small RNA molecules appear to be less affected by tissue processing, and miRNAs demonstrate stable expression levels in FFPE compared with snap frozen paired samples (Li et al. 2007).”
• Human embryonic stem cells express a unique set of microRNAs. (2004, methodology): “More than 300 miRNAs have been reported in diverse eukaryotic organisms so far (Aravin et al., 2003; Dostie et al., 2003; Grad et al., 2003; Lagos-Quintana et al., 2001, 2002, 2003; Lai et al., 2003; Lau et al., 2001; Lee and Ambros, 2001; Lee et al., 1993; Lim et al., 2003b; Llave et al., 2002a;…”
• High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma (2004, background): “…and trigger either translation repression or direct RNA cleavage via RNA interference, depending on the degree of complementarity with the specific target mRNA (Ambros, 2001; Lagos-Quintana et al., 2001; Ruvkun, 2001; Lai, 2002; Pasquinelli, 2002; Ambros et al., 2003; Lagos-Quintana et al., 2003).”