What is immune privilege (not)?

By Ian Galea, I. Bechmann, V. Perry. Trends in immunology, 2007

750 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/d411dc67fee1d5c9242cf6cbcb8233127f91d317

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Ransohoff
2. C. Iadecola
3. V. Perry
4. Helmut Kettenmann
5. A. Cardona
6. U. Hanisch
7. Robert Dantzer
8. B. Barres

In Neurology

1. R. Ransohoff
2. V. Perry
3. C. Iadecola
4. Helmut Kettenmann
5. Keith W. Kelley
6. A. Cardona
7. J. Nicoll
8. U. Hanisch

Citations in the corpus

• The pathobiology of vascular dementia (2013, positive): “The perivascular space, which drains into the subarachnoid space and then into cervical lymphnodes (Laman and Weller, 2013), is the ‘‘afferent arm’’ through which brain antigens reach the systemic immune system (Galea et al., 2007).”
• Microglia: active sensor and versatile effector cells in the normal and pathologic brain (2007, background): “The structural organization (white or gray matter), proximity to the vasculature, BBB features and biochemical micromilieu could impose specific adjustments [51, 52 ].”
• Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology (2008, background): “It has been suggested that the differential capacity of soluble antigens but not antigen-presenting cells to migrate from the brain plays an important role in the relative immunological privilege of the brain [3, 39 ].”
• From inflammation to sickness and depression: when the immune system subjugates the brain (2008, background): “Immune signals from periphery to brain The brain has long been considered an 'immune-privileged' organ but this immune status is far from absolute and varies with age and brain regio”
• The myeloid cells of the central nervous system parenchyma (2010, background): “Indeed, the cellular basis of CNS immune privilege rests mainly on the absence of dendritic cells in the healthy CN”
• The role of inflammation in perinatal brain injury (2015, neutral): “sense alarm signals from injured parenchymal cells via PRRs and cytokine receptors (1).”