Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

By R. Carare, M. Bernardes-Silva, T. Newman, A. Page, J. Nicoll, V. Perry, R. Weller. Neuropathology and Applied Neurobiology, 2008

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A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β (2012, result): “Our identification of paravenous pathways, particularly those surrounding the medial internal cerebral and caudal rhinal veins, as the primary route for clearance is in contrast to some studies identifying para-arterial sheaths as pathways for tracer clearance (26, 27).”
A new look at cerebrospinal fluid circulation (2014, methodology): “Clearance of solutes along this pathway could be prevented by cardiac arrest [83].”
Glymphatic MRI in idiopathic normal pressure hydrocephalus (2017, result): “, 2017), but contradictory to studies where intraparenchymal injection of tracers has been used (Carare et al., 2008; Bakker et al., 2016), where it was concluded with retrograde flow.”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “Drainage of some brain interstitial fluid does occur in the perivascular spaces between blood vessel walls and brain parenchyma (Carare et al. 2008; Weller et al. 2008).”