Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1

By R. Kleemann, A. Hausser, Georg Geiger, R. Mischke, A. Burger-Kentischer, O. Flieger, F. Johannes, T. Roger, Thierry Calandra, A. Kapurniotu and 4 more. Nature, 2000

595 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology

View Paper: https://www.semanticscholar.org/paper/d359db8f27e964c372208efc0b83a79478f87e34

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Aaron Ciechanover
2. A. Schober

In Immunology

1. R. Bucala
2. P. Noble
3. T. Roger
4. Christian Weber
5. E. Lolis
6. Thierry Calandra
7. A. Zernecke

Citations in the corpus

• Macrophage migration inhibitory factor: a regulator of innate immunity (2003, unknown): “Second, the article by Kleemann et al.53 assigns growth-inhibitory and anti-inflammatory functions to MIF that go against what were thought to be two well-established properties of MIF — that is, its capacity to sustain cell growth and to induce proinflammatory responses.”
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. (2002, background): “causes a reversal in CSN5/JAB1 activity, leading to CSN5/ JAB1-dependent increase in p27 (235).”
• MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment (2007, background): “and intracellularly interacts with c-Jun activation domain binding protein-1 (JAB1) (ref”
• MIF regulates innate immune responses through modulation of Toll-like receptor 4 (2001, background): “Given that MIF has been shown to exert intracellular activit”
• MIF Signal Transduction Initiated by Binding to CD74 (2003, methodology): “Whether the binding of MIF to CD74 accounts for all of MIF’s cellular actions is unknown, and perhaps unlikely in light of experiments suggesting a pathway for MIF internalization and binding to Jab1 (30), and continued interest in the biological function of MIF’s NH2-terminal, catalytic domain (28)”
• Investigations on DNA intercalation and surface binding by SYBR Green I, its structure determination and methodological implications. (2004, methodology): “Human embryonal kidney 293 T cells (25) were grown overnight in serum-derived medium RPMI-1640 from Invitrogen Life Technologies (Karlsruhe, Germany) and used as a source for total RNA.”
• CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “, 2001), controls Jab1 transcriptional effects (Kleemann et al., 2000), and suppresses activation-induced, p53-dependent apoptosis (Hudson et al.”