Organ-on-a-Chip Platforms for Studying Drug Delivery Systems
By Nupura S. Bhise, João Ribas, V. Manoharan, Yu Shrike Zhang, A. Polini, Solange Massa, Mehmet Remzi Dokmeci, Ali Khademhosseini. Journal of Controlled Release, 2014
352 citations recorded by the source corpus.
Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems – microscale recapitulations of complex organ functions – promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.
Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/aa20ea388c5d03eb306c3953658d09ee1b4bae2b
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In Biomedical Engineering
In Cellular and Molecular Neuroscience
Citations in the corpus
- Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip (2016, positive): “This endothelialized-myocardium-on-a-chip platform would a so enable testing of nanomedicine [4, 5, 83, 84], such as the interactions between nanopa rticles and the cardiac cells [85-87] as well as those between nanoparticles and the endothelium (e.”