3D Cell Culture Systems: Advantages and Applications
By M. Ravi, V. Paramesh, S. Kaviya, E. Anuradha, F. Solomon. Journal of Cellular Physiology, 2015
1,046 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/deaf487b2559159bd952ea56e04b7e9f2ce627f8
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Citations in the corpus
- Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity (2021, background): “However, 2D culture failed to fully reflect the complex cell–cell paracrine crosstalk and cell-matrix interactions in vivo, resulting in the state of art that the drugs tested with high efficacy in lab always cannot meet the expectations in clinics.(328) In addition, animal models also encountered s”
- Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “…matrix (ECM) in cell behavior, it is now well-accepted that culturing cells in three-dimensional (3D) systems that mimic key factors of tissue is much more representative of the in vivo environment than simple two-dimensional (2D) monolayers (Pampaloni et al., 2007; Ravi et al., 2015).”
- Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, background): “The Taylor cone is a stream of liquid produced at the critical point when the polymer solution is exposed to a high voltage causing it to become charged (Reverchon et al., 2012).”
- Scaffolds for 3D Cell Culture and Cellular Agriculture Applications Derived From Non-animal Sources (2019, background): “Comparisons between 2D and 3D cell culture have revealed significant differences in proliferation, differentiation, drug toxicity resistance, gene expression and protein synthesis (Huyck et al., 2012; Antoni et al., 2015; Ravi et al., 2015; Cavo et al., 2016; Fang and Eglen, 2017; Riedl et al., 2017”