Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression.

By P. Serafini, I. Borrello, V. Bronte. Seminars in Cancer Biology, 2006

826 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d2f7c6175e44903695699afeb8d729f61d0a2edb

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Citations in the corpus

The tumor microenvironment and its role in promoting tumor growth (2008, background): “These cells correspond to CD11bþ/Gr-1þ myeloid progenitor cells in mice (Serafini et al., 2006).”
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (2008, background): “Gr-1+CD11b+ myeloid cells have been demonstrated to be immune suppressive since the 1980s (Almand et al., 2001; Bronte et al., 2000; Gabrilovich et al., 1996; Serafini et al., 2004, 2006; Young and Lathers, 1999).”
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “Thus, while studies in humans and mice have shown a strong correlation between MDSC infiltration and tumor progression (Serafini et al., 2006), these models have all been based on MDSC activation in response to tumor-derived signals.”
Dynamics of the immune reaction to pancreatic cancer from inception to invasion. (2007, background): “vascular endothelial growth factor, and granulocyte macrophage colony-stimulating factor (45), and removal of the primary tumor results in a decrease of MDSC and restores T-cell function (46).”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “canonical MDSC markers Gr1 and CD11b, and gated Gr1 CD11b cells were further analyzed for F4/80, IL-4R , and CD80, markers that are differentially expressed on MDSC isolated from mice with histologically distinct tumors (35, 36).”
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “In various mouse tumor models and in different genetic backgrounds, MDSCs have been described to accumulate in bone marrow, blood, and secondary lymphoid organs such as spleen (19, 21).”
Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β11 (2009, background): “tumor progression, infection, and even immunization (4, 5).”
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy (2011, background): “Human equivalents have been identified as LIN human leukocyte antigen (HLA)–DR−CD33CD11b and CD14HLA-DR cells (40).”
Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice (2009, background): “Notably, they share these features with the so-called myeloidderived suppressor cells (MDSC) [60,78–81], which were originally identified in the context of tumor immune escape mechanisms [78–85], and more recently it has been suggested that they have a role in non-CNS tissue repair [36,37] and in th”
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche (2009, background): “T cell- and NK cell-mediated immune responses (Liu et al., 2007; Serafini et al., 2006).”