Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.

By Colin W. Pouton. European Journal of Pharmaceutical Sciences, 2006

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Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “…of hydrophilic materials in LBF promote the formation of emulsions with smaller particle size (often in the nanometer size range) but also increase the risk of drug precipitation during dispersion owing to a loss of solubilization capacity Pouton, 2006; Cuiné et al., 2007; Mohsin et al., 2009).”
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, background): “Another formulation development approach for class IV compounds is the selection of a better drug candidate with more appropriate physiochemical properties during the lead optimization phase [12,13].”
Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery (2011, background): “From the last decade, oral drug delivery has taken a new dimension with the increasing application of lipids as carriers for the delivery of poorly water-soluble drugs ( 4 ).”
Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update (2008, background): “system in combination with the in vitro tests for these formulations (79).”
Advances in drug delivery systems, challenges and future directions (2023, background): “Recently, lipid-based drug preparations have received a lot of interest, with a specific focus on self-microemulsifying drug-delivery systems (SMEDDS) [66].”