Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

By Surajit Das, Anumita Chaudhury. AAPS PharmSciTech, 2011

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Advances in Oral Drug Delivery (2021, background): “Oral bioavailability of solid dispersible forms of drugs for pediatric use can be improved by using nanoparticle technologies (Das and Chaudhury, 2011).”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, neutral): “…et al., 2009); microemulsion (Doktorovova et al., 2010; Souza et al., 2011); phase inversion (Souto et al., 2007); emulsification by sonication (Das and Chaudhury, 2011); emulsification-solvent-evaporation (ESE) (Lin et al., 2010); solvent diffusion and solvent injection/solvent displacement…”
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application. (2015, methodology): “Common disadvantages of SLNs are: Lipid particle growth, tendency to gelation, dynamics of polymorphic transitions, and their inherent low incorporation rate due to the crystalline structure of the solid lipid.(12,19,25,28-30) Dependent of production method of SLNs, three models of drug incorporatio”
Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies (2021, background): “…hamper ocular bioavailability such as tough blood-ocular barriers, muco-aqueous barrier, lymphatic tear turnover, non-pigmented layer of the ciliary epithelium, nasolacrimal drainage (more than 75% of solutions are drained through nasolacrimal duct) and reflex blinking (Diebold and Calonge 2010).”