The balance between IL-1 and IL-1Ra in disease.

By W. Arend. Cytokine & growth factor reviews, 2002

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Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. (2007, background): “The balance between IL-1h and IL-1Ra plays an important role in normal physiology, and a disruption of this balance may predispose to or enhance disease, as seen in chronic inflammatory bowel disease (20).”
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “Furthermore, we found that IL-1RA, a natural antagonist of the IL-1 receptor that binds to IL-1R and thereby inhibits IL-1b activity (Arend, 2002), blocked IL-1b-induced EGFP expression (Figure 4A; Figure S4F) and IL-6 production (Figure 4E) in MDSCs from cis-NF-kBEGFP transgenic mice.”
Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. (2006, background): “5, whereas IL-1ra increases by a factor of 10–20 (32, 34).”
IL‐1, IL‐18, and IL‐33 families of cytokines (2008, background): “IL-1 has been invoked in the pathophysiology of a variety of inflammatory and immune lung diseases including asthma, pulmonary hypertension, pulmonary fibrosis, and granuloma formation (38).”