SOCS proteins, cytokine signalling and immune regulation

By A. Yoshimura, T. Naka, Masato Kubo. Nature reviews. Immunology, 2007

1,676 citations recorded by the source corpus.

Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling pathways. Studies have shown that SOCS proteins are key physiological regulators of both innate and adaptive immunity. These molecules positively and negatively regulate macrophage and dendritic-cell activation and are essential for T-cell development and differentiation. Evidence is also emerging of the involvement of SOCS proteins in diseases of the immune system. In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function.

Subfields: Immunology, Oncology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/d11ed048bed8c670844526cb6852125b99a9daef

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Citations in the corpus

MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “, an effect that is probably mediated by the targeted suppression of suppressor of cytokine signalling 1 (SOCS1) and/or SHIP1, two negative regulators of cytokine-mediated and TLR signalling pathway”
The Role of Zinc in Antiviral Immunity (2019, background): “These include the suppressors of cytokine signaling (SOCS-1 and SOCS3), which bind and inhibit JAK protein signaling, thus preventing signaling from numerous inflammatory (IL6) and antiviral stimuli (162).”
Janus kinases in immune cell signaling (2009, background): “Two SOCS proteins, SOCS1 and SOCS3, contain a kinase inhibitory region (KIR) that inhibits Jak activity by acting as a pseudosubstrate (35, 36).”
Structure-based prediction of protein-protein interactions on a genome-wide scale (2012, background): “SOCS3 is induced by many cytokines and growth factors and negatively regulates cytokineinduced signal transduction [10].”
Homeostasis of naive and memory T cells. (2008, background): “SOCS-1 is one of eight members of the CIS-SOCS family of negative-feedback regulators of cytokine signal transduction that neutralize the activity of JAKs, and SOCS-1 is upregulated by many cytokines, including IL-2, -4, -7, and -15 (Yoshimura et al., 2007).”
Cytokine signaling modules in inflammatory responses. (2008, background): “The predominant function of Socs proteins is to block the generation of the Stat signal from a cytokine receptor (Alexander and Hilton, 2004; Yoshimura et al., 2007).”
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1 (2009, background): “, IL-15R, and potentially noncytokine signaling pathways, such as Toll-like receptors (TLRs) (Yoshimura et al., 2007).”
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “Likewise, SOCS1 and SOCS3 can attenuate NF-κB activation driven by several cytokines and TLR agonists, although the exact mechanism underlying this inhibitory effect is not entirely clear (33).”
Cross-regulation of Signaling and Immune Responses by IFN-γ and STAT1 (2009, background): “The best-established mechanism by which STATs oppose one another is indirect regulation mediated by SOCS proteins that suppress signaling by cytokine receptors by inhibiting receptor-associated Jaks, binding to and blocking STAT docking sites, and targeting receptors for proteosomal degradation (Yos”