Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core

By Rudolf N. Cardinal, David R. Pennicott, C. Lakmali, Sugathapala, Trevor W. Robbins, Barry J. Everitt. Science, 2001

938 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d0b614648f5ffc6b7b2389b477223a45bf706e37

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Citations in the corpus

Stereotypic behaviour in captive animals: fundamentals and implications for welfare and beyond. (2006, background): “Nucleus accumbens lesions also lead to impulsive choices by rats, in which they cannot resist the lure of a small but immediate reward, even in preference to a large but delayed one (Cardinal et al., 2001).”
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. (2008, neutral): “…atypical DA midbrain neurons might be specifically involved in, for example, working memory (Phillips et al., 2004; Seamans and Yang, 2004; Stefani and Moghaddam, 2006), fear conditioning (Marowsky et al., 2005; Rosenkranz and Grace, 2002), or drug addiction (Cardinal et al., 2001; Dalley”
Neural systems implicated in delayed and probabilistic reinforcement (2006, methodology): “…although the DRL task may also be susceptible to general levels of motor activity: AcbC-lesioned rats are hyperactive (Cardinal & Cheung, 2005; Cardinal et al., 2001; Maldonado-Irizarry & Kelley, 1995; Parkinson, Olmstead, Burns, Robbins, & Everitt, 1999), and hyperactivity would itself tend…”
Weighing up the Benefits of Work: Behavioral and Neural Analyses of Effort-Related Decision Making (2006, neutral): “When rats with excitotoxic lesions of ACC were tested on a task requiring them to decide between an immediately available small reward and a larger but delayed reward, they showed similar patterns of delay discounting to control animals (Cardinal et al., 2001).”
Contrasting Roles of Basolateral Amygdala and Orbitofrontal Cortex in Impulsive Choice (2004, background): “Lesions of prelimbic (PrL) or anterior cingulate (ACC) cortex cause little or no change in impulsive choice (Cardinal et al., 2001) despite strong interconnections with the NAC.”
Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder (2008, background): “These results fit well with animal studies showing that lesions of the NA in the ventral striatum cause impulsive choice in rats, providing evidence that the NA might be involved in the pathogenesis of impulsivity and hyperactivity (Cardinal et al., 2001).”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “…choice, excitotoxic lesions of the nucleus accumbens core subregion produced remarkably potent shifts in choice for small, immediate food reward (Cardinal et al., 2001), a ﬁnding that has been replicated with different types of temporal discounting procedure in several other studies (Basar et…”
Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops (2004, background): “Lesions in the core of the nucleus accumbens in rats result in a tendency to choose small immediate rewards over larger future reward”
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “…well as involvement of the AcbC in the acquisition of drugseeking behaviour (Ito et al. 2004 ) and the ability to tolerate delays to reinforcement (Cardinal et al. 2001) , indicates the importance of the ventral striatum in the neural mechanisms underlying the propensity to seek and work for…”
Metalearning and neuromodulation (2002, background): “It is possible that these different pathways are specialized for reward prediction and action selection in different time scales (Cardinal et al., 2001).”
Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies (2006, neutral): “In addition, lesions to neither anterior cingulate nor prelimbic cortex altered impulsive choice as measured by delay-discounting paradigms (Cardinal et al., 2001).”
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis (2011, background): “Lesions to the NAcc result in impulsive choice in mammals (Cardinal et al., 2001).”