Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system.

By S. Lammel, A. Hetzel, Olga Häckel, I. Jones, Birgit Liss, Jochen Roeper. Neuron, 2008

916 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/8b16156e1f981105a0bcdf82a637c1a1089122eb

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Citations in the corpus

Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “Although the drug-evoked synaptic plasticity in VTA DA neurons is robust, recent studies have demonstrated that these cells are not homogeneous but instead exhibit different electrophysiological and molecular properties depending on the specific brain area to which they project (Lammel et al., 2008;”
Reward and aversion in a heterogeneous midbrain dopamine system (2013, background): “VTA DA neurons projecting to NAc can be subdivided based on their specific projection target (i.e. core versus medial shell versus lateral shell) and these differences may be behaviorally important (Ikemoto, 2007; Lammel et al., 2008, 2011, 2012).”
Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits (2015, background): “…target-defined subpopulations are located in different subregions of the VTA, their excitatory synapses are differentially modulated by rewarding and aversive stimuli, and they receive distinct inputs, which can elicit opposite behaviors when selectively recruited (Lammel et al., 2008, 2011, 2012).”
Whole-brain mapping of direct inputs to midbrain dopamine neurons. (2012, positive): “For example, VTA dopamine neurons are composed of different subgroups that project to distinct areas, have distinct physiological properties , and involve distinct synaptic plasticity in response to cocaine and pain (Lammel et al., 2008; Lammel et al., 2011).”
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement (2011, neutral): “Electrical ICSS experiments have been difficult to interpret in the context of phasic DA neuron activation since electrical stimulation activates a heterogeneous and complex population of neurons (Margolis et al., 2006; Fields et al., 2007; Dobi et al., 2010; Lammel et al., 2008; Histed et al., 2009”
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, positive): “Here, we have attempted to define differences in the experience-dependent modulation of subpopulations of midbrain DA neurons that are categorized based on their projections to different target areas as defined by the presence of retrogradely transported fluorescent beads (Koebbert et al., 2000; Lam”
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli (2009, neutral): “Although dopamine neurons exhibit considerable heterogeneity regarding projection targets and basic pharmacological properties (3-5), it is widely assumed that they exhibit homogenous reward coding across the entire population (1).”
A Single-Cell Atlas of Cell Types, States, and Other Transcriptional Patterns from Nine Regions of the Adult Mouse Brain (2018, background): “Molecular specializations are known to exist in the DA system that are, at least in part, associated with the anatomical location of DA neuron subtypes (Lammel et al., 2008; Poulin et al., 2014).”
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain (2018, background): “Molecular specializations related to anatomical location exist for DA neuron subtypes (Lammel et al., 2008; Poulin et al., 2014), yet it is unclear if ACh-releasing neurons exhibit similar heterogeneity and whether this diversity has a spatial component.”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, neutral): “They are highly heterogeneous and vary by location, morphological characteristics, forebrain targets, afferent influences, firing properties, and content of calciumbinding proteins, ion channels, autoreceptors, DA transporter , and other molecular features (Smith et al, 1996; Sesack and Carr, 2002; ”
Dopamine release in the basal ganglia (2011, background): “However, it is also increasingly recognized that there are subpopulations of DA neurons, especially in the VTA (Margolis et al., 2008; Lammel et al., 2008, 2011; Dobi et al., 2010; Mileykovskiy and Morales, 2011), that have distinct projections, inputs, and electrophysiological characteristics that…”
Natural neural projection dynamics underlying social behavior. (2014, positive): “…fibers in NAc, but not mPFC or BLA (Figure 4H), supporting previous findings that VTA subpopulations projecting to these regions are nonoverlapping (Lammel et al., 2008) and indicating that behavioral effects are not attributable to antidromic spike propagation to collateral projections toward…”
Dopamine in motivational control: rewarding, aversive, and alerting (2010, background): “Furthermore, at least in the VTA, DA neurons can have different cellular properties depending on their projection targets (Lammel et al., 2008; Margolis et al., 2008), and some have the remarkable ability to transmit glutamate as well as dopamine (Descarries et al., 2008; Chuhma et al., 2009;…”