ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

By D. Lim, Seong-tae Kim, Bo Xu, R. Maser, Junyu Lin, J. Petrini, M. Kastan. Nature, 2000

838 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d0791393bc1c1a3a23b4f53070505a9f9884d9f5

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In Cancer Research

1. J. Bartek
2. Stephen P. Jackson
3. J. Lukas
4. T. de Lange
5. R. Abraham
6. T. Stracker
7. J. Petrini
8. M. Kastan

In Molecular Biology

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. T. de Lange
5. R. Abraham
6. C. Lukas
7. J. Petrini
8. T. Stracker

In Oncology

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. R. Abraham
5. T. de Lange
6. C. Lukas
7. T. Halazonetis
8. B. Kaina

Citations in the corpus

• The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis (2001, background): “; however, the former substrate seems more relevant for S-phase arrest induced by IR, as p53 controls the G1 and sustains the G2/M checkpoints, rather than the S-phase checkpoin”
• Regulation and mechanisms of mammalian double-strand break repair (2003, background): “…is believed to facilitate DNA unwinding (Paull and Gellert, 1999), whereas the NBS1 subunit appears to be important for nuclear transport and for transmitting signals from DNA damage sensors to MRN (Gatei et al., 2000b; Lim et al., 2000; Wu et al., 2000; Zhao et al., 2000; DesaiMehta et al., 2001).”
• Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres (2000, background): “The human MRE11 complex functions in DNA-damage detection and induction of an S-phase checkpoin”
• Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM (2004, background): “2C shows that the addition of KU-55933 has no appreciable effects on UV-induced phosphorylation of H2AX on serine 139 (37), NBS1 on serine 343 (38), CHK1 on serine 345 (39), and SMC1 on serine 966 (40).”
• The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer (2003, background): “There is also evidence that ATM-mediated phosphorylation of (Nijmegen breakage syndrome 1 (NBS1) is required to induce S phase arrest during the S phase checkpoint (Lim et al. 2000).”
• Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair (2002, background): “ATM phosphorylates the Nbs1 protein in response to IR, and mutation of the Nbs1 residue that is phosphorylated results in loss of the S-phase checkpoint (114, 201).”
• Defying death after DNA damage (2000, background): “The recent demonstration that ATM links p95/Nbs1 to an S-phase checkpoin”