Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

By Xu-Dong Zhu, B. Küster, Matthias Mann, J. Petrini, T. de Lange. Nature Genetics, 2000

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Protection of mammalian telomeres (2002, background): “…the mammalian Tel1p ortholog, ATM, is involved in telomere signaling (Karlseder et al., 1999), and the Mre11 complex is associated with telomeres (Zhu et al., 2000), raising the possibility that this pathway may be capable of detecting telomere dysfunction without further generation of…”
Alternative lengthening of telomeres in mammalian cells (2002, background): “APBs have also been found to contain a range of proteins involved in DNA recombination and replication: RAD51, RAD52, RPA, MRE11, RAD50, NBS1, BLM and WRN (Table 2) (Johnson et al., 2001; Wu et al., 2000; Yankiwski et al., 2000; Yeager et al., 1999; Zhu et al., 2000).”
Telomeres and telomerase. (2002, methodology): “DNA damage pathway response components have been detected at telomeres of dividing cells by immunofluorescence or crosslinking methods (Zhu et al. 2000).”
How shelterin protects mammalian telomeres. (2008, background): “Rap1 forms a ∼(∼1:1) complex with TRF2 (209) and is dependent on TRF2 for its telomeric localization and stability; most of it is lost upon TRF2 deletion (21).”
Toward maintaining the genome: DNA damage and replication checkpoints. (2002, background): “Mre11-Rad50-Nbs1 The Mre11-Rad50-Nbs1 (MRN) complex localizes to sites of double-strand breaks (DSBs) in vivo and plays vital roles in DNA metabolism, including DSB repair, meiotic recombination, and telomere maintenance (32, 50, 128, 234).”