Programmed cell death as a defence against infection

By Ine Jorgensen, Manira Rayamajhi, Edward A. Miao. Nature reviews. Immunology, 2017

877 citations recorded by the source corpus.

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens. Finally, we describe how the resulting cell corpses — apoptotic bodies, pore-induced intracellular traps (PITs) and neutrophil extracellular traps (NETs) — promote the clearance of infection.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d060d192e8a7e0991df92e148ec909c6689e8936

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. T. Kanneganti
2. Yaqiu Wang
3. R. Malireddi
4. S. Kesavardhana
5. S. B. Kovacs
6. Edward A. Miao

In Molecular Biology

1. T. Kanneganti
2. Yaqiu Wang
3. R. Malireddi
4. S. Kesavardhana
5. S. B. Kovacs
6. Edward A. Miao
7. M. Lamkanfi

Citations in the corpus

• Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, background): “against pathogens, the precise contribution of pyroptosis and other inflammasome-related mechanisms are poorly understood and arose mainly from in vitro assays or bacterial infection models in mice deficient for molecules that compose these platforms (159, 175).”
• ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “Cell death plays key roles in infection and immunity, as programmed cell death is often part of the host anti-microbial strategy (Man and Kanneganti, 2016; Jorgensen et al., 2017; Van Opdenbosch and Lamkanfi, 2019).”
• From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, background): “Growing evidence has shown an interplay between PCD pathways and microbial factors, suggesting that these pathways may have played important roles during mammalian co-evolution with microbes [142,143].”
• Gasdermins: Effectors of pyroptosis (2017, background): “At least five inflammasomes can activate caspase-1[1], driving pyroptosis via gasdermin D.”