Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

By Lidong Liu, T. Wong, M. Pozza, K. Lingenhoehl, Yushan S. Wang, M. Sheng, Y. Auberson, Yu Tian Wang. Science, 2004

1,183 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/d0464ab04941054d01f138faa8b73f8d9f39290a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. D. Selkoe
2. Hongjun Song
3. Fred H. Gage
4. Guo-li Ming
5. L. Mucke
6. B. Lu
7. S. Ge
8. M. Constantine‐Paton

In Cognitive Neuroscience

1. D. Selkoe
2. Hongjun Song
3. Guo-li Ming
4. G. Shankar
5. Koji Yashiro
6. B. Philpot
7. Philip Haydon
8. M. Sheng

Citations in the corpus

• Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression (2004, background): “Since submission of this manuscript, a paper has been published (Liu et al., 2004) suggesting a role for NR2A-containing receptors in LTP and NR2B-containing receptors in LTD in juvenile hippocampus.”
• The tempotron: a neuron that learns spike timing–based decisions (2006, background): “that the polarity of expressed synaptic change results from the balance between separately activated intracellular induction pathways for LTP and LTD (refs”
• Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “Their results provide the exciting observation that the astrocyte controls a form of metaplasticity: whether a synapse exhibits LTP or LTD is controlled by the glial coverage of the synapse and the extent to which D-serine is provided to synaptic NMDARs.”
• Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term (2010, positive): “Some studies in hippocampus and perirhinal cortex showed that ifenprodil and Ro25-6981 block LTD but not LTP (Liu et al., 2004; Massey et al., 2004; Fox et al., 2006; Izumi et al., 2006; Chen et al., 2007), whereas NVP-AAM077 blocks LTP but not LTD (Liu et al., 2004; Massey et al., 2004).”
• NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo (2007, methodology): “However, several recent studies have demonstrated that such a marginal effect may not significantly alter the utility of NVPAAM077 as an NR2A-subunit preferential antagonist under experimental conditions such as in the present study (Liu et al., 2004; Massey et al., 2004; Tigaret et al., 2006).”
• Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. (2012, background): “2006) or desensitization (Liu et al. 2004) and subsequent collapse of dendritic spines (Snyder et al.”
• The yin and yang of neurotrophin action (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=14812">NR2B , a key molecule that has been implicated in LTD but not in LT”
• Regulation of NMDA Receptor Subunit Expression and Its Implications for LTD, LTP, and Metaplasticity (2008, methodology): “In contrast to one study demonstrating that ifenprodil completely blocks hippocampal LTD (Liu et al., 2004a), studies in three independent laboratories consistently found that hippocampal LTD is insensitive to NR2B blockade by ifenprodil (Morishita et al., 2006).”
• Regulation of extrasynaptic signaling by polysialylated NCAM: Impact for synaptic plasticity and cognitive functions (2017, background): “Previous studies also suggested that activation of GluN2A-NMDARs might preferentially promote the induction of LTP, while GluN2B-contianing NMDARs mediate the induction of LTD (Liu et al., 2004; Massey et al., 2004; Papouin et al., 2012).”
• Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, methodology): “…receptors over GluN2B-containing receptors, was used to evaluate physiological roles of GluN2A and GluN2B in rodent models of synaptic plasticity and neurotoxicity before a full pharmacological characterization was completed (Liu et al., 2004b; Massey et al., 2004; Zhou and Baudry, 2006).”
• A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. (2007, positive): “NMDAR subtypes are known to be differentially expressed during early postnatal neuronal development and have recently been proposed to differentially regulate the form and degree of synaptic plasticity (Barria and Malinow, 2005; Barth and Malenka, 2001; Kim et al., 2005; Liu et al., 2004; Tang et al”
• Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. (2006, background): “A recent study by Thompson and colleagues (Liu et al., 2004a) provides strong additional evidence for the correlation between hippocampal LTP and contextual fear.”