Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.

By L. Mucke, D. Selkoe. Cold Spring Harbor Perspectives in Medicine, 2012

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. (2020, background): “We leave open the discussion of what form of Ab might trigger the pathological changes; some groups have suggested that a toxic halo of oligomeric Ab surrounding amyloid plaques is the bioactive agent (Koffie et al., 2009; Mucke and Selkoe, 2012).”
β-Amyloid accumulation in the human brain after one night of sleep deprivation (2018, background): “Notably, increased ABB in the brain has been associated with impairment of brain function (11, 12).”
Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models (2016, positive): “Alternatively, oAβ binding to synapses may weaken the synapse (4) and expose a C1q receptor.”