Triggered amplification by hybridization chain reaction.

By Robert M. Dirks, Niles A. Pierce. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,050 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d02e504129978e7dde200cbd2e41a87382c854fd

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In Molecular Biology

Citations in the corpus

Thermodynamic Analysis of Interacting Nucleic Acid Strands (2007, positive): “Remarkably, empirical potential functions based on secondary structure alone [41, 31, 23] have great utility for studying the properties of natural and engineered RNA and DNA structures [23, 40, 36, 35, 12].”
Programmable in situ amplification for multiplexed imaging of mRNA expression (2010, neutral): “The original HCR system employed DNA hairpins with 6-nt toeholds/loops and 18-bp stems 7 (resulting in six stacked base pairs plus the opening of a 6-nt hairpin loop per polymerization step).”
Toehold Switches: De-Novo-Designed Regulators of Gene Expression (2014, positive): “Such toehold mechanisms have been extensively used to engineer complex dynamic systems utilizing reconfigurable DNA hairpins in test tubes (Dirks and Pierce, 2004; Yin et al., 2008) and RNA hairpins in fixed tissues (Choi et al., 2010) and for complex in vitro information processing systems (Qian…”
Dynamic DNA nanotechnology using strand-displacement reactions. (2011, neutral): “Kinetically controlled self-assembly has been initially demonstrated with strand-displacement cascades that use hairpins rather than multi-stranded complexe”
Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust (2018, neutral): “1A) that co-exist metastably on lab time scales, storing the energy to drive a conditional selfassembly cascade upon exposure to a cognateDNA initiator sequence (I1) (Dirks and Pierce, 2004; Choi et al., 2014).”
Programming biomolecular self-assembly pathways (2008, neutral): “Nucleic acids show promise as a design medium for engineering dynamic functions, including catalytic hybridization 3–6 , triggered self-assembly 7 and molecular computation 8,9 .”
Challenges and opportunities for structural DNA nanotechnology (2011, positive): “An important development has been stepwise kinetic-control over self-assembly by means of the hybridization chain reactio”