Challenges and opportunities for structural DNA nanotechnology
By A. Pinheiro, Dongran Han, William M. Shih, Hao Yan. Nature Nanotechnology, 2011
1,184 citations recorded by the source corpus.
DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d3a30d2e26abd0c0b3f42f5ba74ba85a60241f7e
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In Molecular Biology
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Citations in the corpus
- Programmable materials and the nature of the DNA bond (2015, background): “The advantage over tile-based assembly is that hybridization occurs frequently via intramolecular interactions on the scaffold strand, resulting in a high local concentration of complementary oligonucleotides that drives the system toward the intended sequence-specific thermodynamic product (48).”
- Towards atomic and close-to-atomic scale manufacturing (2019, background): “applications possible, such as molecular and cellular biophysics, biomimetic systems, energy transfer and photonics, diagnostic, and therapeutics for human health [59].”
- The delivery of therapeutic oligonucleotides (2016, background): “DNA nanostructures represent an exciting new avenue for biotechnology research and development (325,326).”