Pharmacokinetics of vitamin D toxicity.
By Glenville Jones. American Journal of Clinical Nutrition, 2008
918 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/d027f5e0018789141b6398b8b6fbce7210fecdf1
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In Endocrinology, Diabetes and Metabolism
In Nutrition and Dietetics
In Pathology and Forensic Medicine
Citations in the corpus
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “Infectious mycobacterial (TLR2/1 and TLR4) (233, 235), bacterial (TLR4 and TLR6) (242, 243), and viral diseases (TLR 7) (244), as well as autoimmune diseases (TLR7) (245) have all been significantly associated with low serum 25(OH)D levels in cross-sectional studies.”
- Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. (2010, neutral): “Biochemical measures, median (IQR)e 25-hydroxycholecalciferol, nmol/L 53 (40-65) 45 (40-57)”
- Vitamin D and Immune Function (2013, background): “Although serum 25(OH)D levels >150 ng/mL may cause acute vitamin D intoxication with hypercalcemia, hypercalciuria and calcifications in different organs [7,30–33], even prolonged daily intakes of 10,000 IU cholecalciferol are considered to be safe [29] and most cases of vitamin D intoxication have ”
- Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis (2012, background): “At the first site, the liver, vitamins D2 and D3 are converted to 25-hydroxyvitamin D [25(OH)D](4) via the action of 25-hydroxylases (ie, microsomal cytochrome P450 2R1 and mitochondrial cytochrome P450 27A1), which are known to be from the cytochrome P450 group (2, 3).”
- Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1 (2012, background): “Vitamin D levels are normally measured by serum 25(OH)D3 levels, because this form of vitamin D is more stable, whereas the active form of vitamin D has a short half life (5).”
- Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “However, certain conditions like granulomatous conditions [243], genetic disorders [244] or rare polymorphisms of enzymes involved in vitamin D metabolism [245] are associated with an increased risk for vitamin D toxicity.”
- Vitamin D deficiency 2.0: an update on the current status worldwide (2020, background): “Having a long half-life in the tissues, vitamin D accumulation due to excessive intake lasts up to 18 months [48] , and may cause chronic toxic effects such as nephrocalcinosis following hypercalcemia and hypercalciuria [47] .”