Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial.

By K. Sanders, A. Stuart, E. Williamson, J. Simpson, M. Kotowicz, D. Young, G. Nicholson. Journal of the American Medical Association (JAMA), 2010

1,378 citations recorded by the source corpus.

Subfields: Orthopedics and Sports Medicine, Pathology and Forensic Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/adfed30a976ef37b8157df6ca351d3a8f7d5445c

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Citations in the corpus

Vitamin D deficiency 2.0: an update on the current status worldwide (2020, background): “They are no longer recommended because of the higher risk of adverse effects (falls and fractures) associated with them [26] .”
Vitamin D and type 2 diabetes: a systematic review (2011, background): “…D (Sugden et al., 2008; Nagpal et al., 2009; Witham et al., 2010; Jorde et al., 2010a, b), a commonly used clinical approach, the benefit of which has been questioned lately in the setting of studies showing increased risk of adverse outcomes (Dawson-Hughes and Harris, 2010; Sanders et al., 2010).”
European guidance for the diagnosis and management of osteoporosis in postmenopausal women (2008, result): “In contrast, studies with large annual doses of vitamin D have reported an increased risk of hip fracture and, in one study, also of falls [145, 146].”
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “(146) administered 500,000 U vitamin D once yearly for 3 yr or placebo to older postmenopausal women (mean age, 76 yr) at high risk for falling (one third had also suffered previous fractures).”
Vitamin D: Nutrient, Hormone, and Immunomodulator (2018, background): “Recent literature raises the suspicion that administration of a bolus of vitamin D3 higher than 50,000 UI may result in an increased risk of falls and fractures [19,20]; moreover, the mortality related to 25(OH)D3 is a “U shaped curve” and 25(OH)D3 levels higher than 150 nM/L are associated with inc”
Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management (2019, neutral): “However, several trials testing large bolus applications (monthly 60’000 IU (161) to 100’000 IU (162) of vitamin D or annual dosing of 300’000 IU (163) to 500’000 IU (164)) increased fall risk among frail older adults.”
European guidance for the diagnosis and management of osteoporosis in postmenopausal women (2018, result): “In contrast, studies with large annual doses of vitamin D have reported an increased risk of hip fracture and, in one study, and also of falls [167, 168].”
Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline. (2019, background): “posite effect, with an increased risk of fracture (113).”
UK clinical guideline for the prevention and treatment of osteoporosis (2017, background): “is not advised, based on recent reports of an associated increased risk of fracture and falls [63, 64].”