Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges

By A. Chaix, Amir Zarrinpar, Phuong Miu, Satchidananda Panda. Cell Metabolism, 2014

873 citations recorded by the source corpus.

SUMMARY Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9h food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse nutritional challenges, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with pre-existing obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.

Subfields: Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/cff8c82782efbdcab26618cc764ae77617489995

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In Endocrinology, Diabetes and Metabolism

In Physiology

Citations in the corpus

Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting (2017, background): “The most thorough studies of molecular and biochemical responses of hepatic cells to IF are those of mice on TRF fed either a normal or a high-fat diet (61,65).”
Inflammation: depression fans the flames and feasts on the heat. (2015, background): “Time-restricted feeding also reduced inflammation in mice (91).”
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. (2018, positive): “This is consistent with rodent studies, which have reported that both eTRF and other forms of TRF reduce appetite hormones and body weight (Belkacemi et al., 2010, 2011; Chaix et al., 2014; Chung et al., 2016; Duncan et al., 2016; Garcı́aLuna et al., 2017; Hatori et al., 2012; Kudo et al., 2004;Manz”
Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “Time-restricted feeding of mice during 8 hours of the dark phase of the daily cycle does not affect overall calorie intake of mice on a high fat diet, but restores normal circadian rhythms of activity in metabolic pathways and protects the mice against weight gain, fat accumulation, inflammation, gl”
Impact of intermittent fasting on health and disease processes (2016, neutral): “…70% energy restriction every other day (Johnson t al., 2007; Varady et al., 2015); consuming only 500–700 cal two onsecutive days/week (Harvie et al., 2011); and restricting food ntake to a 6–8 h time period daily, which has also been termed time restricted feeding’ (TRF) (Chaix et al., 2014).”
Metabolic Control of Longevity. (2016, background): “Mice kept on an unhealthy high-sugar or high-fat diet combined with daily fasting intervals outcompete non-fasting mice kept on regular chow in endurance tests, suggesting that breaks in between meals may actually be more important than the quality of food (Chaix et al., 2014).”
A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits (2015, background): “…organisms have demonstrated that restricting the time of caloric intake to a window of 8–12 hr without altering the quantity or quality of diet can impart pleiotropic physiological benefits (Chaix et al., 2014; Gill et al., 2015; Hatori et al., 2012; Sherman et al., 2012; Zarrinpar et al., 2014).”
Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome (2019, background): “TRF is effective in reversing aspects of metabolic syndrome in mice in both sexes by reducing body weight, adiposity, glucose intolerance, plasma cholesterol, and plasma triglycerides (Chaix et al., 2014; Chung et al., 2016), and improving heart function in Drosophila (Gill et al.”