Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome

By Michael J. Wilkinson, Emily N. C. Manoogian, Adena Zadourian, Hannah C. Lo, Savannah K. Fakhouri, Azarin Shoghi, Xinran Wang, J. Fleischer, S. Navlakha, Satchidananda Panda and 1 more. Cell Metabolism, 2019

741 citations recorded by the source corpus.

Summary In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of metabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces the risks of metabolic diseases in otherwise healthy individuals. However, patients with diagnosed metabolic syndrome often undergo pharmacotherapy, and it has never been tested whether TRE can act synergistically with pharmacotherapy in animal models or humans. In a single-arm, paired-sample trial, 19 participants with metabolic syndrome and a baseline mean daily eating window of ≥ 14 hours, the majority of whom were on a statin and/or antihypertensive therapy, underwent 10-hour of TRE (all dietary intake within a consistent self-selected 10-hour window) for 12-weeks. We found this TRE intervention improves cardiometabolic health for patients with metabolic syndrome receiving standard medical care including high rates of statin and antihypertensive use. TRE is a potentially powerful lifestyle intervention that can be added to standard medical practice to treat metabolic syndrome.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/3c5de48305ba806e3c20a4c4f439967361803bed