Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.
By Elizabeth F Sutton, R. Beyl, K. Early, W. Cefalu, E. Ravussin, C. Peterson. Cell Metabolism, 2018
1,268 citations recorded by the source corpus.
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism. Men with prediabetes were randomized to eTRF (6-hr feeding period, with dinner before 3 p.m.) or a control schedule (12-hr feeding period) for 5 weeks and later crossed over to the other schedule. eTRF improved insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite. We demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF's effects are not solely due to weight loss.
Subfields: Endocrinology, Diabetes and Metabolism, Physiology
View Paper: https://www.semanticscholar.org/paper/795a10f67d34326c5320a74f38dda5281b072bee
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In Endocrinology, Diabetes and Metabolism
In Physiology
Citations in the corpus
- Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome (2019, background): “Self-reported adverse effects of TRE are rare, but one crossover study (6 h TRE, 8 am-2 pm compared to 12 h, 8 am-8 pm, 5 weeks in each arm) included reports of vomiting (n=1), headaches, increased thirst, and diarrhea (n=2) (Sutton et al., 2018).”
- Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report (2019, background): “improved insulin sensitivity, b-cell responsiveness, blood pressure, oxidative stress, and appetite were shown in the intervention group (128).”