From Birth to Death: The Complex Lives of Eukaryotic mRNAs

By Melissa J. Moore. Science, 2005

1,076 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cfd07c542560c04ab185e1da76df18d73450459e

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In Molecular Biology

Citations in the corpus

Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System (2008, background): “Many RBPs associate with mRNAs at a particular stage in their lives [2].”
In vivo dynamics of RNA polymerase II transcription (2007, background): “Little information exists about the kinetics of this process in live cell”
Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells (2009, neutral): “Besides miRNA regulation, the lost regulatory sequences in the 3 0 UTR can influence mRNA nuclear export and cytoplasmic localization, as well as non-miRNAmediated changes in mRNA stability and translational efficiency (Moore, 2005).”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “mRNP biogenesis involves several nuclear events, including transcription, splicing and 3′-end formatio”
The evolution of gene regulation by transcription factors and microRNAs (2007, background): “jpg" NDATA ITEM> ]> The emergence of complex, multicellular organisms was accompanied, and perhaps facilitated, by dramatic increases in the complexity of gene regulatory mechanism”
Integrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability (2011, background): “RBPs regulate all aspects of the lives of mRNAs (Moore, 2005).”
Dendritic mRNA: transport, translation and function (2007, result): “However, our confidence in the model is bolstered by findings that show similar mechanisms acting in non-neuronal cell”
Specialization and evolution of endogenous small RNA pathways (2007, background): “jpg" NDATA ITEM> ]> Genome expansion in higher plants, animals and other multicellular eukaryotes is partially attributed to an increased capacity for the spatiotemporal control of gene expression that is required for developmen”
An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data (2009, background): “of translation and/or mRNA localization, in this class of genes [40,41].”
N6-methyladenosine Modulates Messenger RNA Translation Efficiency (2015, neutral): “When compared to the transcriptional regulation of mRNA, regulatory pathways at the post-transcriptional level have distinct advantages, including the ability to promptly respond to stimuli, to fine-tune protein amounts, and to execute localized control (Moore, 2005).”