The Landscape of long non-coding RNA classification
By G. S. St Laurent, Claes Wahlestedt, Philipp Kapranov. Trends in Genetics, 2015
1,040 citations recorded by the source corpus.
Advances in the depth and quality of transcriptome sequencing have revealed many new classes of long non-coding RNAs (lncRNAs). lncRNA classification has mushroomed to accommodate these new findings, even though the real dimensions and complexity of the non-coding transcriptome remain unknown. Although evidence of functionality of specific lncRNAs continues to accumulate, conflicting, confusing, and overlapping terminology has fostered ambiguity and lack of clarity in the field in general. The lack of fundamental conceptual un-ambiguous classification framework results in a number of challenges in the annotation and interpretation of non-coding transcriptome data. It also might undermine integration of the new genomic methods and datasets in an effort to unravel function of lncRNA. Here, we review existing lncRNA classifications, nomenclature, and terminology. Then we describe the conceptual guidelines that have emerged for their classification and functional annotation based on expanding and more comprehensive use of large systems biology-based datasets.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/34fd3e6c5d18657d8f83720793d742addde0da56
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Citations in the corpus
- The delivery of therapeutic oligonucleotides (2016, background): “There is a bewildering variety of short and long ncRNAs and understanding of their biological functions is still at an early stage (28).”
- The Potential for microRNA Therapeutics and Clinical Research (2019, background): “…these nonprotein-coding RNAs (ncRNAs) have vastly expanded with ongoing research studies and now include transcripts such as microRNAs (miRNAs), natural antisense transcripts, Piwi-interacting RNA (piRNAs), and long ncRNAs (lncRNAs) (Bartel, 2009; Washietl et al., 2012; St Laurent et al., 2015).”
- LNCcation: lncRNA localization and function (2021, background): “The majority of expressed transcripts do not encode protein, with those >200 nt in length being broadly classified as lncRNAs (Hangauer et al., 2013; Iyer et al., 2015; Managadze et al., 2013; St Laurent et al., 2015; see text box).”