Role of transposable elements in heterochromatin and epigenetic control

By Z. Lippman, Anne-Valerie Gendrel, M. Black, M. Vaughn, N. Dedhia, W. Richard Mccombie, Kimberly Lavine, V. Mittal, B. May, Kristin D. Kasschau and 4 more. Nature, 2004

1,282 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/cf2e94deb0c076eadaca08d384acaa531f800709

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Citations in the corpus

Epigenetic reprogramming and small RNA silencing of transposable elements in pollen (2009, neutral): “DDM1 is the master regulator of TE activity in Arabidopsis, as most TEs lose DNA methylation, repressive histone modifications, and 24 nt siRNAs in ddm1 mutants (Gendrel et al., 2002; Lippman et al., 2004; Lippman et al., 2003).”
The nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin (2013, background): “DDM1 can shift nucleosomes in vitro (Brzeski and Jerzmanowski, 2003), and its mutation has been reported to cause a profound loss of methylation from some TEs and repeats (Jeddeloh et al., 1999), but not from genes (Lippman et al., 2004).”
The role of RNA interference in heterochromatic silencing (2004, background): “Nearly all the targets of DDM1 are transposons and tandem repeats, which are the focus of both DNA and histone methylation in plant genome”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “Several examples that fit the obligatory epigenetic variation category have been described in the literature, including transposon-associated alleles where the presence of the transposon is strictly associated with epigenetic silencing of the nearby coding sequenc”
Widespread dynamic DNA methylation in response to biotic stress (2012, background): “Interestingly, ddm1 mutants, which display CG methylation defects at repeats and transposons but not genes (37), only partially phenocopy the met1 mutants, suggesting that CG methylation represses plant defenses by regulating repeats/ transposons and protein-coding genes.”
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. (2006, background): “Repetitive sequences are subject to repressive epigenetic modifications (Arnaud et al., 2000; Lippman et al., 2004; Martens et al., 2005), which might interfere with the function of the bivalent domains and thus be eliminated by selection.”
Transgenerational Epigenetic Inheritance: myths and mechanisms (2014, neutral): “In some ways, mutants in ddm1 in Arabidopsis resemble mutants in lsd1 in worms, as they both display elevated levels of H3K4me2, especially in heterochromatin (Lippman et al., 2004).”
Transposable elements and the epigenetic regulation of the genome (2007, background): “thaliana , the SWI2/SNF2-like protein DDM1 is specifically required for TE silencing and chromatin condensatio”