Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

By A. Hall, Fiona R. Lucas, P. Salinas. Cell, 2000

715 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/cf0ed211d75b20b7398b7175e60d2da5ae8503dc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Chilton
2. R. Nusse
3. R. Hen
4. Lorenza Ciani
5. Michael E. Greenberg
6. P. Salinas
7. C. Logan

In Developmental Neuroscience

1. R. Nusse
2. R. Hen
3. Lorenza Ciani
4. J. Chilton
5. Michael E. Greenberg
6. P. Salinas
7. Fred H. Gage

Citations in the corpus

• Molecular mechanisms of axon guidance. (2006, background): “…of secreted patterning molecules; two of their features that are particularly interesting with respect to axon guidance are their expression in anteroposterior and dorsoventral gradients in the neural tube and their putative role in synaptogenesis (Ciani and Salinas, 2005; Hall et al., 2000).”
• Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “TGN-derived carriers may also be important for delivery and release of secreted molecules involved in synapse formation such as Wnt family (Hall et al., 2000; Packard et al., 2002) and neuronal activity regulated pentraxin (Narp), which induces clustering of AMPAR (Dityatev and Schachner, 2003).”
• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, background): “Ultrastructural analyses of the cerebellum of Wnt7a mutant mice revealed that axon remodelling is affecte”
• EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. (2000, methodology): “This interaction including WNT-7a, and neuroligin (Hall et al., 2000; occurs at the cell surface and is mediated by the extraScheiffele et al., 2000), have been implicated in regulacellular regions of the two receptors, but does not tion of the formation of presynaptic specializations in require the”
• The Wnt signaling pathway in development and disease. (2004, background): “Female infertility; in males, (Hall et al. 2000, Mullerian duct regression fails Parr & McMahon Delayed maturation of synapses in 1998) cerebellum”
• Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice (2001, background): “Apart from their well-established roles in early development, Wnt signaling and GSK-3b have been shown to participate in postnatal cerebellar granule cell synaptogenesis (Lucas and Salinas, 1997; Hall et al., 2000).”
• Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly (2003, neutral): “Finally, while wnt signaling has been shown to promote synaptic differentiation in the cerebellum (Hall et al., 2000), we show that this pathway is not involved in the presynaptic action of β-catenin in hippocampal neurons.”
• The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. (2003, neutral): “C. was a Human Frontier Science Program Fellow and continuedgens, members of the Wnt family, also play roles in axon as an Arnold and Mabel Beckman Foundation Senior Research Felgrowth and remodeling (Hall et al., 2000; Wang et al., low.”
• Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface (2003, background): “However, the structure of the Hh molecule itself is very similar to that of zinc hydrolases and other enzymes, including bacterial ones (Hall et al., 1995).”